Thursday, November 19, 2015


Insufflation (Latin insufflatio "blowing on" or "into") is the practice of inhaling a substance. Insufflation has medical use as a route of administration for many respiratory drugs used to treat conditions in the lungs (e.g., asthma or emphysema) and paranasal sinus (e.g., allergy).
The technique is common for many recreational drugs and is also used for some entheogens. Nasal insufflation (snorting) is commonly used for many psychoactive drugs because it causes a much faster onset than orally, and bioavailability is usually, but not always, higher than orally. This bioavailability occurs due to the quick absorption of molecules into the bloodstream through the soft tissue in the mucous membrane of the sinus cavity and portal circulation bypass. Some drugs have a higher rate of absorption, and are thus more effective in smaller doses, through this route. Prodrugs, drugs that are metabolized or activated by the liver (such as codeine), should not be insufflated, because they need to be metabolized by the liver to break down into the compounds that are active (drugs absorbed through the GI tract pass through the liver before entering the systemic circulation, where drugs which are insufflated are absorbed directly into the systemic circulation).


Stewart Morgan said...

Your Post is very useful, I am truly happy to post my note on this blog . It helped me with ocean of awareness so I really consider you will do much better in the future.

Morgan Miller said...

This is a brilliant writing and very pleased to find this site. I couldn’t discover to much different information on your blog. I will surely be back again to look at some other important posts that you have in future.