Misophonia, literally “hatred of sound,” is a form of decreased sound tolerance. It is characterized by negative experiences resulting only from specific sounds, whether loud or soft, and is often used interchangeably with the term Selective Sound Sensitivity. The term was coined by American neuroscientists Pawel Jastreboff and Margaret Jastreboff.Unlike hyperacusis, misophonia is specific for certain sounds. Little is known about the anatomical location of the physiological abnormality that causes such symptoms but it is most likely high central nervous system structures. It is believed to result from abnormally strong connections between the autonomic and limbic systems in the brain, rather than over-activity of the auditory system. A subcortical route within non-classical auditory pathways may be indicated in the condition. Misophonia appears to reflect the auditory symptoms of sensory processing disorder, which typically presents in multiple sensory modes, but more research is needed to understand if, or how the conditions may be related.